Department of Neurophysiology

Head: prof. dr hab. Małgorzata SKUP

e-mail: m.skup@nencki.gov.pl

 

Secretariat: Grażyna RYBKA

Surgery Room: Ewa NOSECKA

Histology Unit: Agnieszka KĘPCZYŃSKA

Electronic workshop: Wojciech BORKOWSKI

 

The Department was founded in 1946 by Jerzy Konorski. Its major research is anatomical and functional connectivity of the developing and mature central nervous system in health and disease. The Department consists of eleven research groups, each focusing on a different neuroscience theme (http://www.nencki.gov.pl/en/working-groups).


 

 

 

 

Sensory systems (visual system of the cat and somatosen- sory system of the rat) are investigated by the groups led by Prof. Waleszczyk and Prof. Wróbel and are devoted to basic functional physiology, as well as contextual mechanisms influencing perception. Additionally, these groups study the codes for movement perception in the extrageniculate visual pathway.

Regeneration and plasticity in rats is investigated by four groups: neurodegeneration in rodent models of nerve injury potential treatments, including pharmacological, nerve grafts, locomotor training and neurotrophin signaling and cell adhesion with the use of AAV-mediated gene transfer (groups led by J. Czarkowska-Bauch and U. Sławińska); morphological changes of neural plasticity including extracellular proteolysis and glial contributions (group led by G. Wilczyński); molecular and in vivo research on the function of the basal forebrain cholinergic system and beta-amyloid-induced toxicity in Alzheimer’s disease (group led by G. Niewiadomska).

Emotion and memory in rats are investigated by two groups. The role of the limbic structures in emotion and social behavior, as well as the influence of psychotomimetic compounds on limbic activity are investigated by the groups led by Prof. Kasicki and Dr. Knapska. Learning strategies used in a variety of tests such, as defensive and alimentary conditioning, spatial tasks and recognition, and the roles of information transfer is also investigated by Dr. Knapska’s group.

Neuropsychology research is the conducted by two groups. Research topics include hemispheric asymmetry, cognitive functions, sex-related differences in functional brain orga- nization, mechanisms of language,left-handedness and dyslexia. Close cooperation with colleagues at clinics and hospitals enables these groups to research cognitive deficits in stroke, epileptic and Parkinsonian patients, as well as in patients with cochlear implants and children with developmental disorders (Prof. Grabowska and Prof. Szeląg groups).

Neuroinformatics is researched by Prof. Wójcik’s group whose investigations are aimed at the development of tools and models, and putting them to use to understand neural processing of sensory information gathered by electrophysi- ological, fMRI and behavioral studies

Ethology is investigated by Prof. Godzinska’s group. This group uses ants as models in comparative research devoted to ontogeny and the neurochemical basis of aggressive and social behavior

Despite the wide scope of studies, two common topics inte- grate the research carried out in the Department: 1) intrinsic mechanisms of behavioral neurophysiology and 2) plasticity of the nervous system. The traditional Wednesday seminars allow for the exchange of new ideas and hot discoveries between the research groups. Seminars are also the plat- form for discussion of the lectures delivered by eminent scientists from all over the world, who visit the Depart- ment. Thematic seminars on ethology, behavior, neuronal systems, neuroinformatics and psychophysiology, as well as regular Journal Clubs, are designed to keep track of the modern trends in neuroscience. A two-day integration party combining scientific and social events is organized each spring for all members of the Department. On this occasion Ph.D. students report their annual achievements and awards are given for the best presentations

Dynamic cooperation with leading international institutes facilitates implementation of new research techniques which are made available to all member of the Institute. These techniques pertain to include histology, in vitro slice electrophysiology, HPLC and modern behavioral setup equipped with digital recording, telemetry and analyzing facilities. The Department has recently established a Polish node of the international neuroinformatics network, INCF (www.neuroinf.pl).

During the last thirty years many international conferences and schools on a variety of neuroscience topics have been organized by our Departmental staff. Staff members serve frequently on committees of international brain research organizations (FENS, EBBS, INCF) and are editorial board members of neuroscience journals (Eur. J. Neurosci., Neuro- informatics, ANE). Importantly, the Polish Neuroscience Society, founded in 1991 by former and current members of the Department, continues successfully its integrative and organizational role under the Presidency of Julita Czarkowska-Bauch (2009-2011). The recent successful organization of the first FENS Featured Regional Meeting (2009), annual Brain Awareness Weeks (www.ptbun.org.pl) and the Advanced Course in Computational Neuroscience under auspices of FENS-IBRO (www.neuroinf.pl/accn) have been organized with substantial involvement of the Departmental staff.

Selected publications:

 

Siuda-Krzywicka K., Bola Ł., Paplińska M., Sumera E., Jednoróg K., Marchewka A., Śliwińska M., Amedi A., Szwed M. (2016) Massive cortical reorganization in sighted Braille readers. eLife pii: e10762. doi: 10.7554/eLife.10762.


Dębska A., Łuniewska M., Chyl K., Banaszkiewicz A., Żelechowska A., Wypych M., Marchewka A., Pugh K.R., Jednoróg K. (2016) Neural basis of phonological awareness in beginning readers with familial risk of dyslexia-Results from shallow orthography. Neuroimage 132:406-416.

 

Nowak K., Oron A., Szymaszek A., Leminen M., Näätänen R., Szelag E. (2016) Electrophysiological indicators of the age-related deterioration in the sensitivity to auditory duration deviance. Front Aging Neurosci 8:2. doi: 10.3389/fnagi.2016.00002.

 

Duda W., Wesierska M., Ostaszewski P., Vales K., Nekovarova T., Stuchlik A. (2016). MK-801 and memantine act differently on short-term memory tested with different time-intervals in the Morris water maze test. Behav Brain Res. pii: S0166-4328(16)30299-6. doi: 10.1016/j.bbr.2016.05.024.

 

Tang Z., Luo O.J., Li X., Zheng M., Zhu J.J., Szalaj P., Trzaskoma P., Magalska A., Wlodarczyk J., Ruszczycki B., Michalski P., Piecuch E., Wang P., Wang D., Tian S.Z., Penrad-Mobayed M., Sachs L.M., Ruan X., Wei C.L., Liu E.T., Wilczynski G.M., Plewczynski D., Li G., Ruan Y. (2015) CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. Cell 163(7):1611-27.

 

Mikosz M., Nowak A., Werka T., Knapska,, E. (2015). Sex differences in social modulation of learning in rats. Scientific reports 5, 18114.  

 

Koss D.J., Robinson L., Mietelska-Porowska A., Gasiorowska A., Sepcic K., Turk,T., Jaspars M., Niewiadomska G., Scott R.H., Platt B., Riedel G. (2015). Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits. Cellular and molecular life sciences : CMLS72, 4613-4632.

 

Sergeeva E.G., Bola M., Wagner S., Lazik S., Voigt N., Mawrin C., Gorkin A.G., Waleszczyk W.J., Sabel B.A., Henrich-Noack P. (2015) Repetitive Transcorneal Alternating Current Stimulation Reduces Brain Idling State After Long-term Vision Loss. Brain Stimul.  http://dx.doi.org/10.1016/j.brs.2015.06.006I.

 

Kotlewska I., Nowicka A. (2015). Present self, past self and close-other: event-related potential study of face and name detection. Biological Psychology, 110:201-11. doi: 0.1016.

 

Jednoróg K., Bola Ł., Mostowski P., Szwed M., Boguszewski P.M., Marchewka A., Rutkowski P. (2015). Three-dimensional Grammar in the Brain: Dissociating the Neural Correlates of Natural Sign Language and Manually Coded Spoken Language. Neuropsychologia, 71: 191-200.

 

Zakiewicz I.M., Majka P., Wójcik D.K., Bjaalie J.G., Leergaard TB. (2015) Three-Dimensional Histology Volume Reconstruction of Axonal Tract Tracing Data: Exploring Topographical Organization in Subcortical Projections from Rat Barrel Cortex. PLoS One 10 (9):e0137571.

 

Mochol G., Hermoso-Mendizabal A., Sakata S., Harris K.D., de la Rocha J. (2015)  Stochastic transitions into silence cause noise correlations in cortical circuits. Proc Natl Acad Sci U S A. 17;112(11):3529-34.

 

Hall M.H., Magalska A., Malinowska M., Ruszczycki B., Czaban I., Patel S., Ambrożek-Latecka M., Zołocińska E., Broszkiewicz H., Parobczak K., Nair R.R., Rylski M., Pawlak R., Bramham C.R., Wilczyński G.M. (2015)  Localization and regulation of PML bodies in the adult mouse brain. Brain Struct Funct. 2015 May 9.

 

Dzwonek J., Wilczynski G.W. (2015) CD44: molecular interactions, signaling and functions in the nervous system. Front Cell Neurosci. ; 9: 175.

 

Sobolewski A., Kublik E., Swiejkowski D.A., Kamiński J., Wróbel A. (2015)   Alertness opens the effective flow of sensory information through rat thalamic posterior nucleus. Eur J Neurosci.; 41(10):1321-31. doi: 10.1111/ejn.12901.

 

Jednoróg K., Marchewka A., Altarelli I., Monzalvo K., van Ermingen-Marbach M., Grande M., Grabowska A., Heim S., Ramus, F. (2015)   How reliable are grey matter disruptions in developmental dyslexia? Insights from a large-scale voxel-based morphometry study. Human Brain Mapping, 36: 1741–1754.

 

Melis V., Zabke C., Stamer K., Magbagbeolu M., Schwab K., Marschall P., Veh R.W., Bachmann S., Deiana S, Moreau P.H., Davidson K., Harrington K.A., Rickard J.E., Horsley D., Garman R., Mazurkiewicz M., Niewiadomska G., Wischik C.M., Harrington C.R., Riedel G., Theuring F. (2015)  Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration. Cell Mol Life Sci. ;72(11):2199-222.

Gorkiewicz T., Balcerzyk M., Kaczmarek L., Knapska E. (2015)   Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala. Front. Cell. Neurosci., doi: 10.3389/fncel.2015.00073.


Czechowski W., Godzińska E.J. (2015) Enslaved ants: not as helpless as they were thought to be. Insectes Sociaux 62 (1): 9-22.

 

Jednoróg K., Gawron N., Marchewka A., Heim S., Grabowska A. (2014). Cognitive subtypes of dyslexia are characterized by distinct patterns of grey matter volume. Brain Structure & Function. 219 (5): 1697-1707.

 

Sławińska U., Miazga K, Jordan L.M. (2014).  5-HT2 and 5-HT7 receptor agonists facilitate plantar stepping in chronic spinal rats through actions on different populations of spinal neurons. Front Neural Circuits. 8:95.

 

Ito S., Magalska A., Alcaraz-Iborra M., Lopez-Atalaya J.P., Rovira V., Contreras-Moreira B., Lipinski M., Olivares R., Martinez-Hernandez J., Ruszczycki B., Lujan R, Geijo-Barrientos E., Wilczynski G.M., Barco A. (2014). Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction. Nat Commun. 5:4450.
 

Wypych M., Nagy A., Mochol G., Foik A., Benedek G., Waleszczyk W.J. (2014). Spectral characteristics of phase sensitivity and discharge rate of neurons in the ascending tectofugal visual system. PLoS One. 9:e103557.

 

Głąbska H, Potworowski J., Łęski S. , Wójcik D. K. (2014). Independent components of neural activity carry information on individual populations. PLoS One. 9:e105071.

 

Godzińska E. J., Wróbel A. (2014). Capturing the essence of decision making should not be oversimplified. Behavioral and Brain Sciences. 37: 85.

 

Ziemlińska E., Kügler S., Schachner M., Wewiór I., Czarkowska-Bauch J., Skup M. (2014). Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PLoS One. 9:e88833.

 

Gajewska-Woźniak, O., Skup M., Kasicki S., Ziemlińska E., Czarkowska-Bauch J. (2014).  Enhancing proprioceptive input to motoneurons differentially affects expression of neurotrophin 3 and brain-derived neurotrophic factor in rat hoffmann-reflex circuitry. Plos One 8:e65937.

 

Szelag, E., Lewandowska, M., Wolak T., Seniow J., Poniatowska, R., Pöppel E., Szymaszek A. (2014). Training in rapid auditory processing ameliorates auditorycomprehension in aphasic patients: A randomized controlled pilot study. Journal of the Neurological Sciences, 338: 77-86.

 

Wnuk A., Kostowski W., Korczyńska J., Szczuka A., Symonowicz B., Bieńkowski P., Mierzejewski P., Godzińska E. J. (2014). Brain GABA and glutamate levels in workers of two ant species (Hymenoptera: Formicidae): Interspecific differences and effects of queen presence/absence. Insect Science, doi:10.1111/1744-7917.12076.

 

Łęski S., Lindén H., Tetzlaff T., Pettersen K. H., Einevoll G. T. (2013). Frequency dependence of signal power and spatial reach of the local field potential. PLOS Computational Biology, 9 e1003137.

 

Olszewski M., Piasecka J., Goda S.A., Kasicki S., Hunt M.J. (2013). Antipsychotic compounds differentially modulate high-frequency oscillations in the rat nucleus accumbens: a comparison of first- and second-generation drugs. International Journal  of Neuropsychopharmacology, 16(5): 1009-1020.

 

Tacikowski P., Brechmann A., Nowicka A. (2013). Cross-modal pattern of brain activations associated with the processing of self- and significant other’s name. Human Brain Mapping, 34: 2069-2077.
 

Slawinska U., Miazga K., Cabaj A. M., Leszczyńska A.N., Majczynski H., Nagy J.I., Jordan L.M. (2013).  Grafting of fetal brainstem 5-HT neurons into the sublesional spinal cord of paraplegic rats restores coordinated hindlimb locomotion. Experimental Neurology, 247:  572–58.

 

Walczak A., Szczepankiewicz A.A., Ruszczycki B., Magalska A., Zamlynska K., Dzwonek J., Wilczek E., Zybura-Broda K., Rylski M., Malinowska M., Dabrowski M., Szczepinska T., Pawlowski K., Pyskaty M., Wlodarczyk J., Szczerbal I., Switonski M., Cremer M., Wilczynski G.M. (2013). Novel Higher-Order Epigenetic Regulation of the Bdnf Gene upon Seizures. Journal of Neuroscience, 33:2507-2511.

 

Wasik U., Schneider G.,  Mietelska-Porowska A., Mazurkiewicz M., Fabczak H., Weis S., Zabke C., Harrington C.R., Filipek A., Niewiadomska G. (2013). Calcyclin binding protein and Siah-1 interacting protein in Alzheimer’s disease pathology: neuronal localization and possible function. Neurobiology of Aging, 34: 1380-1388.