Laboratory of Bioenergetics and Biomembranes

Head: Jerzy Duszyński

 

Degrees:

1993 Professor of Biological Sciences, nomination by the President of the Republic of Poland, Nencki Institute of Experimental Biology, PAS

1983 DSc Habil, Nencki Institute of Experimental Biology, PAS

1975 PhD in Biology, Nencki Institute of Experimental Biology, PAS

1971 MSci in Biology, University of Warsaw

 

Research trainings:

1985-1986, France (1 year in the laboratory of P.V. Vignais, Nucleaire Centre, Grenoble) Numerous   shor t-term   internships   in laboratories of P.V. Vignais (Grenoble), France J.M. Tager (Amsterdam), W. Kunz (Magdeburg), F.  Palmieri  (Bari),  J.P.  Mazat  (Baurdeaux), V.P. Skulachev (Moscow), Russia

1976-1978, 1992 the USA (3 years in the laboratories of J.R. Williamson, Pennsylvania University, Philadelphia and K.F. LaNoue, PennState Univ., Hershey), USA

 

Professional employments:

2015-present President, the Polish Academy Sciences

2008-2009 Undersecretary, Ministry of Science and Higher Education

1971-present Professor, Head of the Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology, PAS

 

Honors and fellowships:

2016-2017 Grant from Philip Morris International

2011- 2014 Human Frontiers Scientific Program

2012 Member Academia Europaea

2007 Member of the Polish Academy of Sciences

Staff: Violetta Biernat, Karolina Drabik (PhD student), Irina Kamarieva (PhD student), Magdalena Lebiedzińska-Arciszewska, Dominika Malińska, Bernardeta Michalska (PhD student), Małgorzata Partyka (PhD student), Paulina Patalas-Krawczyk (PhD student), Monika Prill (PhD student), Joanna Szczepanowska, Jędrzej Szymański, Jarosław Walczak, Mariusz Więckowski, Lech Wojtczak (Professor emeritus)

 

Research profile:

  • bioenergetics, mitochondrial energy metabolism and energy coupling
  • mitochondrial function in neurodegenerative diseases and in cancer
  • mitochondrial stress signaling – biogenesis and mitophagy
  • mitochondrial dynamics, transport and mitochondrial network

 

Current research activities:

  • molecular composition of the mitochondrial permeability transition pore
  • role of MAM (Mitochondria Associated Membranes) components in cell physiology
  • fusion/fission and morphology of mitochondrial network
  • intracellular dynamics of selected proteins (Drp1 and GBE1)
  • mitochondrial functions in sporadic and familial forms of neurodegenerative diseases
  • (Alzheimer, Parkinson, Amyotrophic Lateral Sclerosis)
  • mitochondrial biogenesis and mitophagy processes in mitochondrial stress signaling
  • (retrograde signaling)
  • involvement of p66Shc protein in the oxidative stress
  • GDSs – glycogen storage diseases: role of glycogen in the nervous system
  • calcium signaling in mitochondrial transport


More information at the web site: duszynskilab.nencki.gov.pl

Selected publications:
 

Oparka M., Walczak J., Malinska D., van Oppen L.M.P.E., Szczepanowska J., Koopman W.J.H.,  Wieckowski M.R. (2016) Quantifying ROS levels using CM-H2DCFDA and HyPer. Methods, S1046-2023(16)30172-4.

 

Wojewoda M., Walczak J., Duszyński J., Szczepanowska J. (2015) Selenite activates the ATM kinase-dependent DNA repair pathway in human osteosarcoma cells with mitochondrial dysfunction. Biochem Pharmacol, 95(3): 170-176.

 

Lebiedzinska-Arciszewska M., Oparka M., Vega Naredo I., Karkucinska-Wieckowska A., Pinton P., Duszyński J., Więckowski M.R. (2015) The interplay between p66Shc, Reactive Oxygen Species and cancer cell metabolism. Eur J Clin Invest, 1:25-31.

 

Suski J.M., Lebiedzinska M., Wojtala A., Duszyński J., Giorgi C., Pinton P., Wieckowski M.R. (2014) Isolation of plasma membrane-associated membranes from rat liver. Nature Protocols, 9(2): 312-322.

 

Szczepanowska J., Malinska D., Wieckowski M.R., Duszynski J. (2012) Effect of mtDNA point mutations on cellular bioenergetics. Biochim Biophys Acta-Bioenerg, 1817(10): 1740-1746.