LABORATORY OF MOLECULAR AND SYSTEMIC NEUROMORPHOLOGY

Head: Grzegorz Wilczyński

 

Degrees:

2016 Professor of Biological Sciences, nomination by the President of the Republic of Poland, Nencki Institute of Experimental Biology, PAS

2002 PhD (summa cum laude), Medical University of Warsaw

1997 MD (summa cum laude), Medical University of Warsaw

 

Research trainings:

1999 Postdoctoral training in the Neuromuscular Center, University of Southern California, Los Angeles, USA

 

Professional employments:

2016-present Professor, Nencki Institute of Experimental Biology, PAS

2010-2016 Associate Professor, Nencki Institute of Experimental Biology, PAS

2006-present Head of the Laboratory of Molecular and Systemic Neuromorphology, Nencki Institute of Experimental Biology, PAS

2006-2010 adjunct

 

Honors and fellowships:

2006 Visiting scientist at University of Oslo, Norway

2002 Visiting scientist at the Leibniz Institute in Magdeburg, Germany

Team award from the Ministry of Science and Higher Education for the research in experimental oncology;

Team award from Head of the Polish Academy of Sciences for the research in neurobiology and Konorski Prize for the best publication in neurobiology

Staff: Artur Choroś, Agnieszka Chwedorowicz (PhD student), Iwona Czaban (PhD student), Agnieszka Czechowska (PhD student), Hubert Doleżyczek, Joanna Dzwonek, Ana Martin Gonzales (PhD student), Dagmara Holm (PhD student), Elżbieta Januszewicz, Patrycja Kruk (PhD student), Katarzyna Krawczyk (PhD student), Adriana Magalska, Monika Malinowska, Gabriela Olech-Kochańczyk (PhD student), Katarzyna Pels, Anna Skupień (PhD student), Andrzej Szczepankiewicz, Paweł Trzaskoma (PhD student)

 

Research profile:

Our research interest focuses on the structural and functional plasticity of the nervous system, in both health and disease. We study phenomena occurring at various levels of organization, including anatomical sub-structures of the brain, the nervous tissue with all its cellular constituents, subcellular-, and macromolecular levels. One major issue that we investigate is the role of neuronal nuclear structure and immediate-early gene expression in learning and behaviour, and in epileptogenesis. Another major project focuses on the role of the extracellular matrix receptors in synaptic plasticity in the brain, this also involves studies of pathological plasticity occurring in various forms of epilepsy. We are also interested in advances of microscopy and tissue-visualization techniques. We cooperate extensively with several groups in the Nencki Institute and at the Jackson Laboratories USA, University of Bergen, Norway, Institute of Neurobiology, Alicante, Spain.



Current research activities:

  • investigation of the neuronal nuclear architecture in plasticity and epileptogenesis
  • studies on the role of CD44, an adhesion and signaling receptor, in neural plasticity.


Selected publications:

 

Roszkowska M., Skupien A., Wójtowicz T., Konopka A., Gorlewicz A., Kisiel M., Bekisz M., Ruszczycki B., Dolezyczek H., Rejmak E., Knapska E., Mozrzymas J.W., Wlodarczyk J., Wilczynski G.M., Dzwonek J. (2016) CD44 – a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines. Mol Biol Cell, 27(25): 4055-4066.

 

Tang Z., Luo O.J., Li X., Zheng M., Zhu J.J,. Szalaj P., Trzaskoma P., Magalska A., Wlodarczyk J., Ruszczycki B., Michalski P., Piecuch E., Wang P., Wang D., Tian S.Z., Penrad-Mobayed M., Sachs L.M., Ruan X., Wei C.L., Liu E.T., Wilczynski G.M., Plewczynski D., Li G., Ruan Y. (2015) CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. Cell, 163(7):1611-1627.

 

Ito S., Magalska A., Alcaraz-Iborra M., Lopez-Atalaya J.P., Rovira V., Contreras-Moreira B., Lipinski M., Olivares R., Martinez-Hernandez J., Ruszczycki B., Lujan R., Geijo-Barrientos E., Wilczynski G.M., Barco A. (2014) Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction. Nat Commun, 5: 4450.

 

Skupien A., Konopka A., Trzaskoma P., Labus J., Gorlewicz A., Swiech L., Babraj M., Dolezyczek H., Figiel I., Ponimaskin E., Wlodarczyk J., Jaworski J., Wilczynski G.M., Dzwonek J. (2014) CD44 regulates dendrite morphogenesis through Src tyrosine kinase-dependent positioning of the Golgi apparatus. J Cell Sci, 127(23): 5038-5051.

 

Walczak A., Szczepankiewicz A.A., Ruszczycki B., Magalska A., Zamlynska K., Dzwonek J., Wilczek E., Zybura-Broda K., Rylski M., Malinowska M., Dabrowski M., Szczepinska T., Pawlowski K., Pyskaty M., Wlodarczyk J., Szczerbal I., Switonski M., Cremer M., Wilczynski G.M. (2013) Novel higher-order epigenetic regulation of the Bdnf gene upon seizures. J Neurosci, 33(6): 2507-2511.