LABORATORY OF NEUROBIOLOGY OF VISION

Head: Wioletta Joanna Waleszczyk

 

Degrees:

2006 DSc Habil, Nencki Institute of Experimental Biology, PAS

1995 PhD in Biology, Nencki Institute of Experimental Biology, PAS

1988 MSc in Physics, Faculty of Physics, University of Warsaw

 

Research trainings:

1997-2000 Post-doctoral training in the Bogdan Dreher’s Laboratory of Adult and Developing Visual System, at the Department of Anatomy and Histology, University of Sydney, Australia

1988-1997 Doctoral and post-doctoral training in the Laboratory of Visual Perception in the Nencki Institute of Experimental Biology, PAS

 

Professional employments:

2013-present Head of the Laboratory of Visual Neurobiology in the Nencki Institute of Experimental Biology, PAS

2009 Visiting scientist, University of Sydney, Australia

2000-present   Assistance   and   Associate   Professor at the Nencki Institute of Experimental Biology, PAS

1997-2000 Research Associate, Department of Anatomy and Histology, University of Sydney, Australia

1988-1997 Research Assistant, Department of Neurophysiology, Nencki Institute of Experimental Biology, PAS

 

Honors and fellowships:

2017-present Editor-in-Chief, Acta Neurobiologiae Experimentalis

201-present Member of the Neurobiology Committee, Polish Academy of Sciences

2011-2015 Governing Board Member and Secretary-General of the Polish Society for Neuroscience

Staff: Marek Bekisz, Urszula Malinowska, Anna Posłuszny, Ryszard Cetnarski (PhD student), Piotr Dzwiniel (PhD student), Katarzyna Jurewicz (PhD student), Katarzyna Kordecka (PhD student), Katarzyna Paluch (PhD student), Ida Raciborska (PhD student), Ninad Shendye (PhD student), Marek Waligóra (PhD student), Agnieszka Wierzbicka, Andrzej Wróbel, Jacek Rogala (voluntier), Anna Wójcik-Gryciuk (voluntier)
 

 

Research profile:

 

The research in the laboratory focuses on functional processing of visual information with strong aspects directed to translational science. The specific goals include: coding of visual information, function of the geniculate and extrageniculate pathway and plasticity following damage of the visual system and cognitive functions of the human brain related to vision. Translational studies concern rehabilitation of visual functions with use of various methods: visual stimulation, noninvasive current stimulation and gene therapy.

 

Methods used in our laboratory include:

  • in vitro intracellular recordings, single-, multi-unit and LFP/EP recordings from subcortical and cortical visual structures in animals; intrinsic signal optical imaging;
  • EEG/EP and fMRI recordings in humans;
  • non-invasive current stimulation;
  • sensory and behavioral trainings, neurofeedback;
  • computational analysis of electrophysiological signals and modeling.

 

Current Research Activities

Information processing in the cortico-thalamic sensory systems

  • the role of primary and secondary sensory pathways in different behavioral situations;
  • the role of thalamic and cortical inhibition in different behavioral situations - physiology and modeling;
  • ex vivo studies of functional mechanisms in subcortical and cortical neuronal networks in brain slices using intracellular recordingswith whole-cell patch-clamp method.

The role of the extrageniculate visual pathway

  • information processing in the subcortical structures of extrageniculate visual pathway (response properties of visual neurons, oscillatory activity, brain state-dependent modulation of neuronal activity);

Electrophysiological correlates of visual attention in cat and human

  • the role of the EEG beta frequency band in attentive vision – temporal analysis (frequency, phase and amplitude envelopes) of LFPs registered from different parts of cat’s thalamo-cortical system during behavioral task based on intermingled trials of delayed spatial discrimination of visual or auditory stimuli;
  • the role of the EEG alpha and beta frequency bands in attentive vision – spatio-temporal analysis of cortical attentional systems during task and resting state.

Cognitive functions of the human brain

  • electrophysiological (EEG) and BOLD (fMRI) correlates of attention and working memory. The validation of neurofeedback-EEG method.

Mechanisms of plasticity in the visual system following damage

  • visual information processing in the visual pathway after local retinal lesion, retinal neurodegeneration and cortical stroke.

Rehabilitation of visual functions

  • influence of visual training and noninvasive current stimulation on visual information processing.

Cortical plasticity in the model of learning

  • plastic changes in the sensory cortex induced by classical conditioning.

 

Selected publications:

 

Jurewicz K, Paluch K, Kublik E, Rogala J, Mikicin M, Wróbel A (2018) EEG-neurofeedback training of beta band (12–22 Hz) affects alpha and beta frequencies. A controlled study of a healthy population. Neuropsychologia 108:13-24.

 

Dzwiniel P, Gola M, Wójcik-Gryciuk A, Waleszczyk WJ. (2017) Specvis: Free and open-source software for visual field examination. PLoS One. 12(10):e0186224.

 

Rogala J, Jurewicz K, Paluch K, Kublik E, Cetnarski R, Wróbel A. (2016) The Do’s and Don’ts of Neurofeedback Training: A Review of the Controlled Studies Using Healthy Adults. Front. Hum. Neurosci. 10:301.

 

Bekisz M, Bogdan W, Ghazaryan A, Waleszczyk WJ, Kublik E, Wróbel A. (2016) The Primary Visual Cortex Is Differentially Modulated by Stimulus-Driven and Top-Down Attention. PLoS One 11(1):e0145379.

 

Foik AT, Kublik E, Sergeeva EG, Tatlisumak T, Rossini PM, Sabel BA, Waleszczyk WJ. (2015) Retinal origin of electrically evoked potentials in response to transcorneal alternating current stimulation in the rat. Invest Ophthalmol Vis Sci. 56(3):1711-1718.