LABORATORY OF NEUROBIOLOGY OF VISION

Head: Wioletta Joanna Waleszczyk

 

Degrees:

2006 DSc Habil, Nencki Institute of Experimental Biology, PAS

1995 PhD in Biology, Nencki Institute of Experimental Biology, PAS

1988 MSc in Physics, Faculty of Physics, University of Warsaw

 

Research trainings:

1997-2000 Post-doctoral training in the Bogdan Dreher’s Laboratory of Adult and Developing Visual System, at the Department of Anatomy and Histology, University of Sydney, Australia

1988-1997 Doctoral and post-doctoral training in the Laboratory of Visual Perception in the Nencki Institute of Experimental Biology, PAS

 

Professional employments:

2013-present Head of the Laboratory of Visual Neurobiology in the Nencki Institute of Experimental Biology, PAS

2009 Visiting scientist, University of Sydney, Australia

2000-present   Assistance   and   Associate   Professor at the Nencki Institute of Experimental Biology, PAS

1997-2000 Research Associate, Department of Anatomy and Histology, University of Sydney, Australia

1988-1997 Research Assistant, Department of Neurophysiology, Nencki Institute of Experimental Biology, PAS

 

Honors and fellowships:

2017-present Editor-in-Chief, Acta Neurobiologiae Experimentalis

201-present Member of the Neurobiology Committee, Polish Academy of Sciences

2011-2015 Governing Board Member and Secretary-General of the Polish Society for Neuroscience

Staff: Marek Bekisz, Ryszard Cetnarski (PhD student), Piotr Dzwiniel (PhD student), Katarzyna Jurewicz (PhD student), Katarzyna Kordecka (PhD student), Katarzyna Paluch (PhD student), Ida Raciborska (PhD student), Jacek Rogala, Ninad Shendye (PhD student), Anna Wieczorek-Taraday (PhD student), Agnieszka Wierzbicka, Andrzej Wróbel

 

Research profile:

 

The research in the laboratory focuses on the functional processing of visual informa- tion with strong aspects directed to translational science. The specific goals include: cod- ing of visual information, function of the extrageniculate pathway and plasticity following damage of the visual pathway. Translational studies concern rehabilitation of visual func- tions with the use of various methods: visual stimulation, noninvasive current stimulation and gene therapy.

Methods used in our laboratory include:

• in vitro intracellular recordings, single-, multi-unit and LFP/EP recordings from subcortical and cortical visual structures in behaving animals; intrinsic signal optical imaging

• EEG/EP and fMRI recordings in humans

• non-invasive current stimulation

• sensory and behavioral training

• computational analysis of electrophysiological signals and modeling.

 

Current research activities:

 

• Electrophysiological correlates of visual attention in cat

– the role of the EEG beta frequency band in attentive vision – temporal analysis (frequency, phase and amplitude envelopes) of LFPs registered from different parts of cat’s thalamo-cortical system during behavioral task based on intermingled trials of delayed spatial discrimination of visual or auditory stimuli

• Cognitive functions of the human brain

– electrophysiological (EEG) and BOLD (fMRI) correlates of attention and working memory. The validation of neurofeedback-EEG method

• Information processing in the cortico-thalamic sensory systems

– the role of primary and secondary sensory pathways in different behavioral situations;

– the role of thalamic and cortical inhibition in different behavioral situations – physiology and modeling

– ex vivo studies of functional mechanisms in subcortical and cortical neuronal networks in brain slices using electrophysiological intracellular recordings with whole-cell patch-clamp method

• The role of the extrageniculate visual pathway

– information processing in the subcortical structures of extrageniculate visual pathway (response properties of visual neurons, oscillatory  activity, brain  state-dependent modulation of neuronal activity)

•  Mechanisms of plasticity in the visual system following damage

– visual information processing in the visual pathway after retinal lesion, retinal neurodegeneration, cortical stroke

• Rehabilitation of visual functions

– influence of visual training and noninvasive current stimulation on visual information processing.

 

Selected publications:

 

Rogala J., Jurewicz K., Paluch K., Kublik E., Cetnarski R., Wróbel A. (2016) The Do’s and Don’ts of Neurofeedback Training: A Review of the Controlled Studies Using Healthy Adults. Front. Hum. Neurosci, 10:301.

 

Bekisz M., Bogdan W., Ghazaryan A., Waleszczyk W.J., Kublik E., Wróbel A. (2016) The Primary Visual Cortex Is Differentially Modulated by Stimulus-Driven and Top-Down Attention. PLoS One, 11(1):e0145379.

 

Foik A.T., Kublik E., Sergeeva E.G., Tatlisumak T., Rossini P.M., Sabel B.A., Waleszczyk W.J. (2015) Retinal origin of electrically evoked potentials in response to transcorneal alternating current stimulation in the rat. Invest Ophthalmol Vis Sci, 56(3): 1711-1718.

 

Sobolewski A., Kublik E., Świejkowski D.A., Kamiński J., Wróbel A. (2015) Alertness opens the effective flow of sensory information through rat thalamic posterior nucleus. Eur J Neurosci, 41: 1321-1331.

 

Wypych M., Wang C., Nagy A., Benedek G., Dreher B., Waleszczyk W.J. (2012) Standardized F1 - A consistent measure of strength of modulation of visual responses to sine-wave drifting gratings. Vision Res, 72: 14-33.