Laboratory of Neuroplasticity

Head: Małgorzata Kossut

 

Degrees:

Professor of Biological Sciences, nomination by the President of the Republic of Poland, Nencki Institute of Experimental Biology, PAS

 

Research trainings:

University of Pennsylvania
University of Oxford
Max Planck Institute for Brain Research

 

Professional employments:

Professor and Head of the Neuroplasticity Laboratory, Nencki Institute of Experimental Biology, PAS
University of Social Sciences and Humanities

 

Honors and fellowships:

Polish Academy of Arts and Sciences (corresponding member)
Polish Academy of Sciences (full member)

 

Staff: Maria Bierzyńska, Kalina Burnat, Anita Cybulska-Kłosowicz, Grzegorz Dobrzański (PhD student), Katarzyna Giertuga (PhD student), Anna Kozak (PhD student), Monika Liguz-Lęcznar, Aleksandra Różycka (PhD student), Ewa Siucińska, Renata Zakrzewska

 


Research profile:

Cellular, molecular and systemic mechanisms of neuroplasticity are explored in three experimental models:

  • learning-induced plasticity in somatosensory  barrel cortex of rodents. We investigate the role of GABA-ergic inhibition in modifications of cortical sensory representations by learning
  • reorganization of cerebral cortex after stroke and during ageing. Using mouse model of photothrombotic stroke localized in the vicinity of somatosensory cortex, we  investigate the effectiveness of different anti-inflammatory interventions in preserving functional cortical  plasticity in the acute post-stroke period
  • plasticity of adult cat visual cortex after lesions of central retina, an animal model of brain reorganization after macular degeneration

 

Current research activities:

  • optical recording of vibrissae representations in brain cortex; observations of learning induced plasticity
  • live imaging of axons of somatostatin interneurons in brain cortex after learning and in the aging brain
  • investigations of the role of somatostatin  and VIP interneurons in learning-induced plasticity using chemogenetic tools
  • investigation of participation of electrical synapses in learning-induced plasticity of the barrel cortex
  • examination  of the motion processing pathway involvement in restoration of cortical activity in cat brain after binocular lesions of central retina using behavioral tests, MRI spectroscopy and DTI techniques



Selected publications:

 

Burnat K., Hu TT, Kossut M., Eysel UT., Arckens L. (2017) Plasticity Beyond V1: Reinforcement of Motion Perception upon Binocular Central Retinal Lesions in Adulthood. J Neurosci. 37(37): 8989-8999.

 

Debowska W., Wolak T., Nowicka A., Kozak A., Szwed M., Kossut M. (2016) Functional and Structural Neuroplasticity Induced by Short-Term Tactile Training Based on Braille Reading. Front Neurosci. 10: 460.

 

Jasinska M., Siucinska E., Jasek E., Litwin JA., Pyza E., Kossut M. (2016) Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex. Neural Plast. 2016:9828517.

 

Liguz-Lecznar M., Urban-Ciecko J., Kossut M. (2016) Somatostatin and Somatostatin-Containing Neurons in Shaping Neuronal Activity and Plasticity.Front Neural Circuits. 10:48.

 

Liguz-Lecznar M., Lehner M., Kaliszewska A., Zakrzewska R., Sobolewska A., Kossut M.  (2015) Altered glutamate/GABA equilibrium in aged mice cortex influences cortical Plasticity. Brain Struct Funct, 220(3): 1681-1693.