Patent granted in Poland for an invention from the Nencki Institute

The Patent Office of the Republic of Poland has issued a decision on granting a patent for the invention entitled: "Method for diagnosing remyelinating processes and corrective processes of myelin sheath in patients with diagnosed disseminated sclerosis" (PAT.235340). The results underlying the discovery were obtained by Małgorzata Zawadzka, PhD, DSc, Associate Professor from the Laboratory of Neuromuscular Plasticity, and Katarzyna Konarzewska, PhD, from the Laboratory of Molecular Neurobiology, during the "Innovative methods of stem cells application in medicine" project, POIG.01.01.02-00-109/09.


The purpose of the invention, is a method of detecting myelin sheath of nerve fibers’ repair processes (remyelination), as well as monitoring the differentiation of oligodendrocyte precursor cells during the course of demyelination diseases, mainly multiple sclerosis. The method is based on detection of changes in IL-33 levels in peripheral blood and cerebrospinal fluid. It has been shown that the increase in IL-33 concentration correlates with the early stages of precursor cells’ differentiation, which initiates the repair process. The method can be used within an in-depth diagnosis, and the monitoring of the disease. In particular, it allows the detection of endogenous (spontaneous or stimulated) repair processes in patients with diagnosed multiple sclerosis. The described method can be used to test the efficacy of new therapies, which support the process of endogenous remyelination.